{"id":60787,"date":"2018-11-01T17:23:26","date_gmt":"2018-11-01T17:23:26","guid":{"rendered":""},"modified":"2018-11-01T17:23:26","modified_gmt":"2018-11-01T17:23:26","slug":"les-vertus-cachees-de-la-metformine","status":"publish","type":"post","link":"https:\/\/harissa.com\/news-wp\/les-vertus-cachees-de-la-metformine\/","title":{"rendered":"LES VERTUS CACHEES DE LA METFORMINE"},"content":{"rendered":"

LES VERTUS CACH\u00c9ES DE LA METFORMINE<\/p>\n

La metformine, antidiab\u00e9tique oral commercialis\u00e9 en France depuis 1979 sous l\u2019appellation de glucophage, est le m\u00e9dicament le plus prescrit pour traiter les patients atteints de diab\u00e8te de type 2 et particuli\u00e8rement les patients en surpoids ou ob\u00e8ses gr\u00e2ce \u00e0 son efficacit\u00e9, sa faible capacit\u00e9 \u00e0 provoquer des hypoglyc\u00e9mies et l\u2019absence de prise de poids. En effet, cette mol\u00e9cule r\u00e9duit l\u2019hyperglyc\u00e9mie en inhibant les g\u00e8nes responsables de la production de glucose dans le foie via l\u2019activation de l\u2019AMPK .<\/p>\n

Outre, sa contribution active dans le traitement du diab\u00e8te de type 2, il s\u2019av\u00e8re que la metformine disposerait de beaucoup d\u2019autres vertus m\u00e9dicales. En effet, elle aurait une action anticancer, cardioprotectrice voire m\u00eame neuroprotectrice. Si les \u00e9l\u00e9ments n\u00e9cessaires \u00e0 son bon fonctionnement restent encore myst\u00e9rieux et \u00e9nigmatiques, de s\u00e9rieuses pistes ont d\u2019ores et d\u00e9j\u00e0 \u00e9t\u00e9 d\u00e9velopp\u00e9es.<\/p>\n

 <\/p>\n

Zoom sur les 2 destin\u00e9es m\u00e9dicales inattendues de ce m\u00e9dicaments, a priori banal \u2026<\/h2>\n

La metformine pr\u00e9serve des mutations canc\u00e9rig\u00e8nes et affame les tumeurs\u2026<\/strong>
\nLe patient diab\u00e9tique est plus expos\u00e9 aux risques de d\u00e9velopper un cancer que le reste de la population. En effet, outre le fait d\u2019avoir des facteurs de risques communs : l\u2019\u00e2ge, l\u2019ob\u00e9sit\u00e9, une mauvaise alimentation et la s\u00e9dentarit\u00e9, les m\u00e9canismes du diab\u00e8te, soit l\u2019hyper-insulin\u00e9mie, l\u2019hyperglyc\u00e9mie et l\u2019inflammation, apparaissent comme des facteurs plausibles associ\u00e9s \u00e0 un risque accru de cancer.<\/strong><\/p>\n

Mais coup de th\u00e9\u00e2tre en 2005, \u00e0 l\u2019Universit\u00e9 de Dundee au Royaume-Uni, avec une surprenante d\u00e9couverte : sachant que l\u2019apparition des tumeurs trouverait son origine dans le disfonctionnement d\u2019un g\u00e8ne (LKB1) qui inactiverait l\u2019enzyme AMPK, la metformine activerait cette enzyme AMPK et ainsi r\u00e9duirait l\u2019apparition des tumeurs. Les risques de d\u00e9velopper un cancer diminuent de 25% pour les patients diab\u00e9tiques trait\u00e9s \u00e0 la metformine. Cette constatation a \u00e9t\u00e9 confirm\u00e9e pour les cancers de la prostate, du sein, du pancr\u00e9as et du colon.<\/p>\n

La raison ?<\/h2>\n

La prolif\u00e9ration de cellules canc\u00e9reuses est d\u00e9courag\u00e9e par les actions multiples de la metformine : diminution du taux d\u2019insuline dans le sang et r\u00e9duction de l\u2019inflammation.
\nAu coeur des cellules, elle r\u00e9duit les risques de mutation gr\u00e2ce \u00e0 son inhibition de production de mol\u00e9cules oxydantes n\u00e9fastes pour l\u2019ADN.<\/p>\n

La metformine bloque l\u2019agression du neurone et sa d\u00e9g\u00e9n\u00e9rescence\u2026<\/h2>\n

La maladie d\u2019Alzheimer est une maladie neurod\u00e9g\u00e9n\u00e9rative incurable du tissu c\u00e9r\u00e9bral, qui entra\u00eene la perte progressive et irr\u00e9versible des fonctions mentales et notamment de la m\u00e9moire.
\nElle se caract\u00e9rise par une accumulation toxiques de prot\u00e9ines (ou plaques amylo\u00efdes) autour des neurones produits par la m\u00e9moire. La metformine pousserait les cellules souches neuronales \u00e0 se diff\u00e9rencier et stimulerait ainsi la cr\u00e9ation de nouveaux neurones.
\n\u00c9tudes pr\u00e9liminaires \u00e0 l\u2019appui : chez la souris, la metformine favoriserait la croissance neuronale et mieux encore am\u00e9liorerait la capacit\u00e9 d\u2019apprentissage.<\/p>\n

La metformine est en apparence une simple petite pilule, mais cache en r\u00e9alit\u00e9 de r\u00e9elles perspectives de progr\u00e8s pour la m\u00e9decine, totalement inattendues. En effet, cette mol\u00e9cule semble capable de reproduire sur l\u2019organisme les effets de la restriction calorique, une di\u00e8te stricte dont il a \u00e9t\u00e9 d\u00e9montr\u00e9 sur l\u2019animal qu\u2019elle peut augmenter l\u2019esp\u00e9rance de vie mais aussi prot\u00e9ger du cancer et du cort\u00e8ge de maladies li\u00e9es au vieillissement : r\u00e9duction des risques de maladie neurod\u00e9g\u00e9n\u00e9rative et de maladie cardio-vasculaire gr\u00e2ce \u00e0 sa protection des vaisseaux sanguins.<\/p>\n

Des nombreux essais cliniques sont en cours pour d\u00e9montrer l\u2019int\u00e9r\u00eat de la metformine dans la pr\u00e9vention, la r\u00e9cidive ou le traitement du cancer et des risques cardio-vasculaires.
\nEn ce qui concerne les maladies neurod\u00e9g\u00e9n\u00e9ratrices, il reste \u00e0 prouver que les conclusions amen\u00e9es par les \u00e9tudes pr\u00e9liminaires sur les souris soient \u00e9galement valables pour l\u2019homme.<\/p>\n

En bref, la Metformine n\u2019a pas encore livr\u00e9 tous ses secrets, dont les patients et la communaut\u00e9 m\u00e9dicale peuvent encore attendre beaucoup !<\/p>\n

La metformine, une vieille dame toujours au top de l\u2019actualit\u00e9<\/h2>\n

Les grandes \u00e9tudes sur la prise en charge des diab\u00e9tiques de type 2, initi\u00e9es au XX e si\u00e8cle et publi\u00e9es au d\u00e9but du XXI e (la plupart en 2008), ont bien d\u00e9fini ce que devait \u00eatre un m\u00e9dicament efficace pour ces patients.<\/p>\n

En effet on conna\u00eet les risques qu\u2019il faut pr\u00e9venir gr\u00e2ce \u00e0 ces m\u00e9dicaments, risque d\u2019accidents cardio-vasculaires mais aussi de d\u00e9t\u00e9rioration r\u00e9nale et \u00e0 plus long terme sur-risque de cancer, ainsi que d\u2019hypoglyc\u00e9mies nocturnes susceptibles de favoriser des troubles du rythme cardiaque pouvant conduire \u00e0 la mort subite nocturne.<\/p>\n

On sait \u00e9galement que le diab\u00e8te est une maladie qui s\u2019aggrave avec le temps, cons\u00e9quence de la perte progressive de fonction des cellules b\u00eata-pancr\u00e9atiques productrices d\u2019insuline, et que le diab\u00e9tique a une tendance inexorable \u00e0 prendre du poids, \u00e9volution favoris\u00e9e par la plupart des m\u00e9dicaments actuellement disponibles.<\/p>\n

Un \u00ab bon antidiab\u00e9tique \u00bb<\/em> doit donc id\u00e9alement non seulement \u00eatre efficace pour faire baisser l\u2019HbA1C, t\u00e9moin du contr\u00f4le glyc\u00e9mique, mais aussi minimiser le risque d\u2019hypoglyc\u00e9mies, \u00e9viter la prise de poids, prot\u00e9ger des risques cardiovasculaires, r\u00e9naux et m\u00eame de cancer, enfin ralentir la destruction des cellules b\u00eata.<\/p>\n

Apr\u00e8s plus de 40 ans de vie, apr\u00e8s avoir \u00e9t\u00e9 refus\u00e9e par les am\u00e9ricains pendant plus de 25 ans, la metformine est aujourd\u2019hui le m\u00e9dicament qui se rapproche le plus de ce produit id\u00e9al.<\/p>\n

Il a en effet \u00e9t\u00e9 d\u00e9montr\u00e9 que, outre une bonne efficacit\u00e9 sur la baisse de l\u2019HbA1C, elle n\u2019entra\u00eenait pas de prise de poids, ne provoquait pas d\u2019hypoglyc\u00e9mies, r\u00e9duisait le risque cardiovasculaire et peut-\u00eatre m\u00eame celui de cancer.<\/p>\n

Seuls les m\u00e9dicaments ayant un effet incr\u00e9tine, inhibiteurs des DPP IV et analogues du GLP1, semblent avoir des effets aussi int\u00e9ressants mais sont sur le march\u00e9 depuis moins de 10 ans, et donc ne pr\u00e9sentent peut-\u00eatre pas les m\u00eames garanties de s\u00e9curit\u00e9.<\/p>\n

Alors oui les recommandations ont raison : la metformine est le m\u00e9dicament de 1\u00e8re intention pour tout diab\u00e9tique de type 2 et doit \u00eatre poursuivi aussi longtemps que l\u2019\u00e9tat clinique du patient le permet, et que son syst\u00e8me digestif le tol\u00e8re.<\/p>\n

C.E.E.D<\/p>\n","protected":false},"excerpt":{"rendered":"

LES VERTUS CACH\u00c9ES DE LA METFORMINE La metformine, antidiab\u00e9tique oral commercialis\u00e9 en France depuis 1979 sous l\u2019appellation de glucophage, est le m\u00e9dicament le plus prescrit pour traiter les patients atteints de diab\u00e8te de type 2 et particuli\u00e8rement les patients en surpoids ou ob\u00e8ses gr\u00e2ce \u00e0 son efficacit\u00e9, sa faible capacit\u00e9 \u00e0 provoquer des hypoglyc\u00e9mies et… <\/p>\n","protected":false},"author":1,"featured_media":60788,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[],"tags":[],"class_list":["post-60787","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"yoast_head":"\nLES VERTUS CACHEES DE LA METFORMINE | HARISSA.COM<\/title>\n<meta name=\"description\" content=\"LES VERTUS CACH\u00c9ES DE LA METFORMINE La metformine, antidiab\u00e9tique oral commercialis\u00e9 en France depuis 1979 sous l\u2019appellation de glucophage, est le\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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