{"id":64144,"date":"2020-10-05T17:42:58","date_gmt":"2020-10-05T17:42:58","guid":{"rendered":""},"modified":"2020-10-05T17:42:58","modified_gmt":"2020-10-05T17:42:58","slug":"un-traitement-experimental-israelien-guerit-cinq-cas-graves-du-covid","status":"publish","type":"post","link":"https:\/\/harissa.com\/news-wp\/un-traitement-experimental-israelien-guerit-cinq-cas-graves-du-covid\/","title":{"rendered":"Un traitement exp\u00e9rimental isra\u00e9lien gu\u00e9rit cinq cas graves du COVID"},"content":{"rendered":"<header>\n<p class=\"headline\">Un traitement exp\u00e9rimental isra\u00e9lien gu\u00e9rit cinq cas graves du COVID<\/p>\n<p class=\"underline\">Enlivex Therapeutics affirme avoir administr\u00e9 sa th\u00e9rapie Allocetra \u00e0 des cas graves et critiques \u00e0 l&rsquo;h\u00f4pital de J\u00e9rusalem ; tous sont r\u00e9tablis et test\u00e9s n\u00e9gatifs au coronavirus<span class=\"comments\"> <\/span><\/p>\n<\/header>\n<div class=\"article-content\">\n<div class=\"the-content\">\n<p>La soci\u00e9t\u00e9 isra\u00e9lienne d\u2019immunoth\u00e9rapie Enlivex Therapeutics a d\u00e9clar\u00e9 jeudi que cinq patients dans un \u00e9tat s\u00e9v\u00e8re \u00e0 critique atteints du COVID-19 ont \u00e9t\u00e9 gu\u00e9ris de la maladie quelques jours apr\u00e8s avoir re\u00e7u un traitement exp\u00e9rimental.<\/p>\n<p>Le traitement Allocetra de la compagnie leur a \u00e9t\u00e9 administr\u00e9 dans le cadre d\u2019un essai clinique \u00e0 l\u2019h\u00f4pital Hadassah Ein Kerem de J\u00e9rusalem.<\/p>\n<p>Les trois sujets dans un \u00e9tat grave sont sortis de l\u2019h\u00f4pital 5 jours et demi apr\u00e8s avoir re\u00e7u le traitement, et les deux patients dans un \u00e9tat critique sont sortis apr\u00e8s 8 jours et demi. Ils ont tous \u00e9t\u00e9 test\u00e9s n\u00e9gatifs au coronavirus avant de quitter l\u2019h\u00f4pital, a d\u00e9clar\u00e9 la soci\u00e9t\u00e9.<\/p>\n<p class=\"fi_inContectMark\">\u00ab&nbsp;Aucun effet ind\u00e9sirable s\u00e9rieux li\u00e9 \u00e0 la prise d\u2019Allocetra&nbsp;TM n\u2019a \u00e9t\u00e9 signal\u00e9 chez les patients et le traitement a \u00e9t\u00e9 bien tol\u00e9r\u00e9&nbsp;\u00bb, a-t-il \u00e9t\u00e9 indiqu\u00e9 dans un communiqu\u00e9.<\/p>\n<p class=\"fi_inContectMark\">Ces m\u00e9dicaments sont g\u00e9n\u00e9ralement administr\u00e9s aux patients dans un \u00e9tat mod\u00e9r\u00e9, et Enlivex esp\u00e8re que sa th\u00e9rapie va dor\u00e9navant devenir un traitement pour des cas plus graves.<\/p>\n<p class=\"fi_inContectMark\">Allocetra traite la r\u00e9ponse excessive du syst\u00e8me immunitaire et la r\u00e9ponse inflammatoire que l\u2019on observe parfois chez les patients atteints du COVID-19, \u00e9galement appel\u00e9e choc cytokinique ou \u00ab&nbsp;temp\u00eate de cytokines&nbsp;\u00bb. Le ph\u00e9nom\u00e8ne peut amener le syst\u00e8me immunitaire \u00e0 attaquer s\u00e9rieusement les propres organes du patient, entra\u00eenant la d\u00e9faillance des organes et parfois la mort.<\/p>\n<p class=\"fi_inContectMark\">Les chocs cytokiniques sont difficiles \u00e0 traiter car ce sont des r\u00e9ponses complexes qui impliquent la participation de plusieurs syst\u00e8mes biologiques r\u00e9agissant et interagissant de fa\u00e7on simultan\u00e9e. Les cytokines sont des prot\u00e9ines utilis\u00e9es dans la transmission de signaux cellulaires qui sollicitent les cellules immunes lors d\u2019une r\u00e9ponse immunitaire.<\/p>\n<p class=\"fi_inContectMark\">Allocetra utilise les m\u00e9canismes de r\u00e9gulation du corps pour att\u00e9nuer le choc cytokinique sans nuire au syst\u00e8me immunitaire, a expliqu\u00e9 la compagnie. Le traitement infuse des milliards de cellules apoptotiques pr\u00e9coces, ou cellules mourantes, dans la circulation sanguine. Les macrophages et les cellules dendritiques, les premiers \u00ab&nbsp;secouristes&nbsp;\u00bb du corps, se nourrissent de ces cellules apoptotiques, lib\u00e9rant moins de signaux d\u2019alerte de cytokines et calmant le choc cytokinique.<\/p>\n<p class=\"fi_inContectMark\">La soci\u00e9t\u00e9 avait d\u00e9j\u00e0 d\u00e9montr\u00e9 l\u2019innocuit\u00e9 du m\u00e9dicament dans le traitement d\u2019un petit groupe de patients atteints de septic\u00e9mie et pr\u00e9voit d\u00e9sormais de lancer des essais cliniques de phase II pour des patients touch\u00e9s par le coronavirus dans un \u00e9tat grave ou critique.<\/p>\n<p class=\"fi_inContectMark\">Enlivex, bas\u00e9e \u00e0 Ness Tsiona, est une soci\u00e9t\u00e9 pharmaceutique d\u2019immunoth\u00e9rapie au stade clinique, qui se focalise sur l\u2019\u00e9quilibre du syst\u00e8me immunitaire. Elle a \u00e9t\u00e9 fond\u00e9e en 2005. Allocetra est le traitement principal de la compagnie et le plus avanc\u00e9 dans les tests cliniques.<\/p>\n<p class=\"fi_inContectMark\">Enlivex se n\u00e9gocie \u00e0 la Bourse de New York sous le symbole ENLV. Le cours de son action a bondi d\u2019environ 50&nbsp;% jeudi.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Un traitement exp\u00e9rimental isra\u00e9lien gu\u00e9rit cinq cas graves du COVID Enlivex Therapeutics affirme avoir administr\u00e9 sa th\u00e9rapie Allocetra \u00e0 des cas graves et critiques \u00e0 l&rsquo;h\u00f4pital de J\u00e9rusalem ; tous sont r\u00e9tablis et test\u00e9s n\u00e9gatifs au coronavirus La soci\u00e9t\u00e9 isra\u00e9lienne d\u2019immunoth\u00e9rapie Enlivex Therapeutics a d\u00e9clar\u00e9 jeudi que cinq patients dans un \u00e9tat s\u00e9v\u00e8re \u00e0 critique&hellip;&nbsp;<\/p>\n","protected":false},"author":1,"featured_media":64145,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[],"tags":[],"class_list":["post-64144","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Un traitement exp\u00e9rimental isra\u00e9lien gu\u00e9rit cinq cas graves du COVID | HARISSA.COM<\/title>\n<meta name=\"description\" content=\"Un traitement exp\u00e9rimental isra\u00e9lien gu\u00e9rit cinq cas graves du 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